Anti-trypsin product description and directions
Anti-trypsin product description and directions£º
Recombinant human alpha-antitrypsin is a glycoprotein serine class of protease inhibition, a wide range of substrate specificity. The mature alpha-antitrypsin molecular weight of 52000 Seoul rectify the isoelectric point (pl) of 4.8, containing 10-12% polysaccharide. Its structure is composed of 394 amino acid residues and three oligosaccharide side chains. Sources of human plasma alpha-antitrypsin synthesized by hepatocytes, a serine protease inhibitor, can inhibit a variety of serine endo-peptidase (serine residues endopeptidase) - trypsin, chymotrypsin, urokinase, renin, plasma factors, collagenase, plasmin, thrombin, elastase activity. alpha-antitrypsin in addition to inhibit the enzyme, but also inhibition of pulmonary mast cell degranulation, inhibition of histamine release from alveolar macrophages to produce the factor, tumor necrosis factor (TNF), leukotriene B4 release.
AAT accounted for 90% inhibition of protease activity in serum, is the main protease inhibitors in serum. Can effectively inhibit the damaging effects of elastase on the formation of the lung tissue. Therefore, If AAT missing in the body case, elastase can not be suppressed, long-term damage the lungs or cause pulmonary disease, can cause liver cell damage and lead to cirrhosis, liver disease or liver cancer. Low plasma AAT can be found in the respiratory distress syndrome. AAT deficient (ZZ-type, SS, and even MS phenotype) often accompanied by emphysema appeared in the early years (20-30 years).
For emphysema, bronchiectasis, pancreatic fibrosis, chronic bronchitis, asthma, psoriasis, the chronic problem of treatment;
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